�One of the world's longest and largest trials of internal secretion replacement therapy (HRT) has found that post-menopausal women on HRT gain significant improvements in quality of life.
The results of the latest sketch by the WISDOM research team (Women's International Study of long Duration Oestrogen after Menopause) are promulgated today on the British Medical Journal website http://www.bmj.com.
The study involved 2130 postmenopausal women in the UK, Australia and New Zealand, and assessed the shock of combined oestrogen and progestogen endocrine therapy on the women's quality of life. The average historic period of women in this study was 13 years after change of life and almost participants did not get menopausal symptoms.
"Our results show that hot flushes, night sweats, wakefulness and joint pains were less common in women on HRT in this age group. Sexuality was also improved," says Professor Alastair MacLennan, leader of the Australian arm of WISDOM and head of Obstetrics & Gynaecology at the University of Adelaide, Australia.
"Overall, calibre of life measures improved. Even when women did not deliver hot flushes and were well past menopause, in that respect was a small just measurable melioration in quality of life and a noted melioration in sleep, sexuality and joint nisus. HRT users also had more breast tenderness and discharge compared to those on a placebo," he says.
Dr Beverley Lawton, Head of WISDOM New Zealand, says: "These new data should be added to the risk/benefit equation for HRT. The quality of life benefits of HRT may be greater in women with more wicked symptoms dear menopause. New research suggests that HRT taken from near menopause avoids the cardiovascular risks seen when HRT is initiated many years after menopause."
Professor MacLennan says studies such as those conducted by WISDOM "enable the risks of HRT to be rock-bottom and its benefits maximized when the treatment is individualized to each woman".
"Early start-up side effects canful usually be alleviated by adjusting the treatment," he says. "For most women with significant menopause symptoms the benefits of HRT outweigh the risks. The latest analyses of the main semipermanent randomized control trial of HRT (The Women's Health Initiative) shew that breast cancer is not increased by oestrogen-only HRT and is just increased in women exploitation combined oestrogen and progestin HRT afterward seven age of utilisation. This increased risk is less than 0.1% per year of use.
"If a woman feels that HRT is needed for quality of life, then doctors privy find the safest regime for her. She fanny try going off HRT every 45 years, and can then make an informed pick about whether she takes and continues HRT."
The WISDOM research is independent of the pharmaceutical industry and has been funded by UK, Australian and New Zealand government research bodies.
University of Adelaide
Level 1, 115 Grenfell St.
Adelaide 5005
Australia
http://www.adelaide.edu
More info
Tuesday, 26 August 2008
Saturday, 16 August 2008
Low Vitamin D Levels Associated With Chronic Pain In Women
�Low vitamin D levels may chip in to continuing pain among women, suggests research published ahead of print in the Annals of the Rheumatic Diseases.
The findings are based on the blood analyses and pain scores of almost 7000 45 twelvemonth old men and women from across England, Scotland and Wales, all of whom were born during one week in March 1958.
Smokers, non-drinkers, the overweight and the underweight all reported higher rates of chronic pain.
The extent of chronic widespread pain did not variegate among work force according to vitamin D levels. However, this was not the case for women.
Women with vitamin D levels between 75 and 99 mmol/litre had the last rates of this type of hurting, at just over 8%.
Women with levels of less than 25 mmol/litre had the highest rates, at 14.4%.
There appeared to be a J shaped curve, with the prevalence of widespread painful sensation at 10% or higher among those with vitamin D levels above 99 mmol/litre.
The findings were not explained by sexuality differences in lifestyle or social factors, such as levels of physical action and time spent open, say the authors.
And at the age of 45, few of the women would have entered the change of life, a period during which bone mineral density waterfall as oestrogen levels dwindle.
But by way of possible explanations, the authors point to osteomalacia, a disease of extreme vitamin D insufficiency, which is associated with isolated or generalised osseous tissue pain. The hormonally active form of vitamin D is too involved in the rule of immune system responses.
Around one in 10 of the population suffers from chronic widespread pain in the neck at whatever one time, say the authors.
The causes are not fully understood, just social and psychological factors are known to affect the sensation and reporting of pain.
Vitamin D and chronic widespread pain in a white middle aged British population: evidence from a cross sectional population study
Online First AnnRheum Dis2008 interior: 10.1136/ard/2008.090456
Click here to scene article on-line
Annals of The Rheumatic Rheumatic Diseases
Annals of the Rheumatic Diseases (ARD) is an external peer brushup journal committed to promoting the highest standards of scientific exchange and education. It covers all aspects of rheumatology, which includes the spectrum of musculoskeletal conditions, arthritic disease, and connective tissue disorders. ARD publishes basic, clinical, and translational scientific research. Concise scientific communicating is encouraged and peer reviewed proceedings of international meetings ar featured. Educational papers include state of the artistic production reviews, "how to" articles and educational cases that focus on problems faced in clinical practice. The journal was first published in 1939 and has an authorative global Editorial Board and a growing international readership.
The Rheumatic Rheumatic Diseases
More information
The findings are based on the blood analyses and pain scores of almost 7000 45 twelvemonth old men and women from across England, Scotland and Wales, all of whom were born during one week in March 1958.
Smokers, non-drinkers, the overweight and the underweight all reported higher rates of chronic pain.
The extent of chronic widespread pain did not variegate among work force according to vitamin D levels. However, this was not the case for women.
Women with vitamin D levels between 75 and 99 mmol/litre had the last rates of this type of hurting, at just over 8%.
Women with levels of less than 25 mmol/litre had the highest rates, at 14.4%.
There appeared to be a J shaped curve, with the prevalence of widespread painful sensation at 10% or higher among those with vitamin D levels above 99 mmol/litre.
The findings were not explained by sexuality differences in lifestyle or social factors, such as levels of physical action and time spent open, say the authors.
And at the age of 45, few of the women would have entered the change of life, a period during which bone mineral density waterfall as oestrogen levels dwindle.
But by way of possible explanations, the authors point to osteomalacia, a disease of extreme vitamin D insufficiency, which is associated with isolated or generalised osseous tissue pain. The hormonally active form of vitamin D is too involved in the rule of immune system responses.
Around one in 10 of the population suffers from chronic widespread pain in the neck at whatever one time, say the authors.
The causes are not fully understood, just social and psychological factors are known to affect the sensation and reporting of pain.
Vitamin D and chronic widespread pain in a white middle aged British population: evidence from a cross sectional population study
Online First AnnRheum Dis2008 interior: 10.1136/ard/2008.090456
Click here to scene article on-line
Annals of The Rheumatic Rheumatic Diseases
Annals of the Rheumatic Diseases (ARD) is an external peer brushup journal committed to promoting the highest standards of scientific exchange and education. It covers all aspects of rheumatology, which includes the spectrum of musculoskeletal conditions, arthritic disease, and connective tissue disorders. ARD publishes basic, clinical, and translational scientific research. Concise scientific communicating is encouraged and peer reviewed proceedings of international meetings ar featured. Educational papers include state of the artistic production reviews, "how to" articles and educational cases that focus on problems faced in clinical practice. The journal was first published in 1939 and has an authorative global Editorial Board and a growing international readership.
The Rheumatic Rheumatic Diseases
More information
Thursday, 7 August 2008
Idaho campaign button features the wrong Larry
Some Democratic campaign buttons made for distribution in Idaho show an unlikely pair: Democratic presidential candidate Barack Obama and Republican Sen. Larry Craig. But don't expect the halt Republican to throw his support behind Obama or for the presidential candidate to ask Craig to change his mind and run for Senate over again. Apparently the button maker picked a picture of the wrong Idaho Larry. The 3-inch button by Tigereye Design was intended to evidence Obama beside Larry LaRocco, the Democratic candidate for U.S. Senate. Craig is not seeking re-election after his pick up in a Minnesota drome restroom sexuality sting.
LaBeouf arrested
Actor Shia LaBeouf, who starred as a motorcycle-riding wetback in the latest Indiana Jones adventure film, was arrested on suspicion of drunken driving Sunday after a dawn wreck, regime said. LaBeouf was nerve-racking to ready a left turn at a West Hollywood intersection around 3 a.m. when his pickup collided with another vehicle, wheeling the hand truck over. The 22-year-old role player was taken to Cedars-Sinai Medical Center and was being treated for injuries to his left helping hand and a knee, as well as a minor head injury. A woman passenger in LaBeouf's truck and the driver of the other vehicle were not severely injured.
At the Movies
Batman soundless hot
Batman fever continued over the weekend, with ticket sales for "The Dark Knight" far outpacing the competition and breaking a fresh batch of box office records. "The Dark Knight" sold an estimated $75.6 trillion in tickets at North American theaters from Friday to Sunday, and $314.2 million in tickets domestically in its
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